Data from a clinical study of three sets of extracorporeal circulation in heart-lung machines

Description

Three sets of extracorporeal circulation in heart-lung machines: treatments H and B, and standard S. Twelve (S and H each) and eleven (B) male adult patients have been considered. The analysis is based on a set of laboratory parameters restricted to the blood coagulation system, characterized by three primary endpoints (each as quotient from post- and pre-surgery values). Higher values indicate a better treatment effect. For more details, see Kropf et al. (2000).

Usage

data(coagulation)

Format

A data frame with 35 observations on the following 5 variables.

Patient

a numeric vector, the patients' number

Thromb.count

a numeric vector

ADP

a numeric vector

TRAP

a numeric vector

Group

a factor with levels B, H, S specifying the treatments, where S is the standard

Source

Kropf, S. et al. (2000): Multiple comparisons of treatments with stable multivariate tests in a two-stage adaptive design, including a test for non-inferiority. Biometrical Journal 42, 951-965.

References

Hasler, M. and Hothorn, L.A. (2011): A Dunnett-type procedure for multiple endpoints. The International Journal of Biostatistics 7, Article 3, <DOI:10.2202/1557-4679.1258>.

Examples

data(coagulation)
str(coagulation)