R: Childhood Cancer Study of Khan et al. (2001)

khan2001 {sda} | R Documentation

## Childhood Cancer Study of Khan et al. (2001)

### Description

Gene expression data (2308 genes for 88 samples) from the microarray study of Khan et al. (2001).

### Usage

    data(khan2001)

### Format

`khan2001$x` is a 88 x 2308 matrix containing the expression levels. Note that rows correspond to samples, and columns to genes. The row names are the original image IDs, and the column names the orginal probe labels.

`khan2001$y` is a factor containing the diagnosis for each sample ("BL", "EWS", "NB", "non-SRBCT", "RMS").

`khan2001$descr` provides some annotation for each gene.

### Details

This data set contains measurements of the gene expression of 2308 genes for 88 observations: 29 cases of Ewing sarcoma (EWS), 11 cases of Burkitt lymphoma (BL), 18 cases of neuroblastoma (NB), 25 cases of rhabdomyosarcoma (RMS), and 5 other (non-SRBCT) samples.

### Source

The data are described in Khan et al. (2001). Note that the values in `khan.data$x` are logarithmized (using natural `log`) for normalization.

### References

Khan et al. 2001. Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks. Nature Medicine 7:673–679.

### Examples

    # load sda library
    library("sda")

    # load full Khan et al (2001) data set
    data(khan2001)
    dim(khan2001$x) # 88 2308
    hist(khan2001$x)
    khan2001$y # 5 levels

    # data set containing the SRBCT samples
    get.srbct = function()
    {
      data(khan2001)
      idx = which( khan2001$y == "non-SRBCT" )
      x = khan2001$x[-idx,]
      y = factor(khan2001$y[-idx])
      descr = khan2001$descr[-idx]

      list(x=x, y=y, descr=descr)
    }

    srbct = get.srbct()
    dim(srbct$x)   # 83 2308
    hist(srbct$x)
    srbct$y # 4 levels

[Package sda version 1.3.7 Index]