R: Get Per-Feature Theta

getNormTheta {propr} | R Documentation

## Get Per-Feature Theta

### Description

The `getNormTheta` function calculates the differential proportionality between each feature and a set of normalization factors. When the normalization factors correctly remove the compositional bias, the resultant thetas indicate differential expression (DE). However, unlike other DE tests, the p-value for differential proportionality is not linked to the normalization factors. Here, normalization factors only affect the interpretation, not the statistics.

### Usage

    getNormTheta(object, norm.factors)

### Arguments

`object` | Any `propd` object.
`norm.factors` | A numeric vector. The effective library size normalization factors (e.g., from edgeR or DESeq2).

### Details

For use in conjunction with `getColours`.

### Value

A numeric vector. A theta for each feature.

[Package propr version 4.2.6 Index]