R: The 70 gene signature of the Netherlands Cancer Institute for...

Netherlands Cancer Institute 70 gene signature {penalized} | R Documentation

## The 70 gene signature of the Netherlands Cancer Institute for prediction of metastasis-free survival, measured on 144 independent lymph node positive patients.

### Description

A `data.frame` of 144 lymph node positive breast cancer patients on metastasis-free survival, 5 clinical risk factors, and gene expression measurements of 70 genes found to be prognostic for metastasis-free survival in an earlier study. The included variables are

time

  Metastasis-free follow-up time (months).

event

  Event indicator. 1 = metastasis or death; 0 = censored.

Diam

  Diameter of the tumor (two levels).

N

  Number of affected lymph nodes (two levels).

ER

  Estrogen receptor status (two levels).

Grade

  Grade of the tumor (three ordered levels).

Age

  Patient age at diagnosis (years).

TSPYL5...C20orf46

  Gene expression measurements of 70 prognostic genes.

### Usage

    data(nki70)

### Format

A `data.frame`.

### Note

The 70 gene signature was trained on lymph node negative patients only.

### References

M.J. van de Vijver, Y.D. He, L.J. van 't Veer, H. Dai, A.A.M. Hart, D.W. Voskuil, G.J. Schreiber, J.L. Peterse, C. Roberts, M.J. Marton, M. Parrish, D. Atsma, A. Witteveen, A. Glas, L. Delahaye, T. van der Velde, H. Bartelink, S. Rodenhuis, E.T. Rutgers, S.H. Friend, and R. Bernards (2002). A gene-expression signature as a predictor of survival in breast cancer. New England Journal of Medicine 347 (25), 1999–2009.

[Package penalized version 0.9-50 Index]