R: Pbc3 data

Pbc3 {pec} | R Documentation

## Pbc3 data

### Description

PBC3 was a multi-centre randomized clinical trial conducted in six European hospitals. Between 1 Jan. 1983 and 1 Jan. 1987, 349 patients with the liver disease primary biliary cirrhosis (PBC) were randomized to either treatment with Cyclosporin A (CyA, 176 patients) or placebo (173 patients). The purpose of the trial was to study the effect of treatment on the survival time. However, during the course of the trial an increased use of liver transplantation for patients with this disease made the investigators redefine the main response variable to be time to “failure of medical treatment” defined as either death or liver transplantation. Patients were then followed from randomization until treatment failure, drop-out or 1 Jan, 1989; 61 patients died (CyA: 30, placebo: 31), another 29 were transplanted (CyA: 14, placebo: 15) and 4 patients were lost to follow-up before 1 Jan. 1989. At entry a number of clinical, biochemical and histological variables, including serum bilirubin, serum albumin, sex, age were recorded.

### Format

A data frame with 349 observations on the following 15 variables.

ptno

  patient identification

unit

  hospital (1: Hvidovre, 2: London, 3: Copenhagen, 4: Barcelona, 5: Munich, 6: Lyon)

tment

  treatment (0: placebo, 1: CyA)

sex

  (1: males, 0: females)

age

  age in years

stage

  histological stage (1, 2, 3, 4)

gibleed

  previous gastrointestinal bleeding (1: yes, 0: no)

crea

  creatinine (micromoles/L)

alb

  albumin (g/L)

bili

  bilirubin (micromoles/L)

alkph

  alkaline phosphatase (IU/L)

asptr

  aspartate transaminase (IU/L)

weight

  body weight (kg)

days

  observation time (days)

status

  status at observation time (0: censored, 1: liver transplantation, 2 : dead)

### Source

Andersen and Skovgaard. Regression with linear predictors.

### References

Andersen and Skovgaard. Regression with linear predictors. Springer, 2010.

### Examples

    data(Pbc3)

[Package pec version 2022.03.06 Index]