R: modlib: Pharmacokinetic models

modlib_pk {mrgsolve} | R Documentation

## modlib: Pharmacokinetic models

### Description

modlib: Pharmacokinetic models

### Arguments

`...` | passed to update

### Details

See `modlib_details` for more detailed descriptions of parameters and compartments.

The `pk1cmt` model is parameterized in terms of `CL`, `VC`, `KA1` and `KA2` and uses compartments `EV1`, `EV2`, and `CENT`. The `pk2cmt` model adds a `PERIPH` compartment and parameters `Q` and `VP` to that of the one-compartment model. Likewise, the three-compartment model (`pk3cmt`) adds `PERIPH2` and parameters `Q2` and `VP2` to that of the two-compartment models. All pk models also have parameters `VMAX` (defaulting to zero, no non-linear clearance) and `KM`.

### Value

an object of class `packmod`

### Model description

All pk models have two extravascular dosing compartments and potential for linear and nonlinear clearance.

- `pk1cmt`: one compartment pk model using ODEs

- `pk2cmt`: two compartment pk model using ODEs

- `pk3cmt`: three compartment pk model using ODEs

- `pk1`: one compartment pk model in closed-form

- `pk2`: two compartment pk model in closed-form

- `popex`: a simple population pk model

[Package mrgsolve version 0.11.1 Index]