R: modlib: PK/PD Model parameters, compartments, and output...

modlib_details {mrgsolve} | R Documentation

## modlib: PK/PD Model parameters, compartments, and output variables

### Description

modlib: PK/PD Model parameters, compartments, and output variables

### Compartments

- `EV1`, `EV2`: extravascular dosing compartments

- `CENT`: central PK compartment

- `PERIPH`: peripheral PK compartment

- `PERIPH2`: peripheral PK compartment 2

- `RESP`: response PD compartment (irm models)

### Output variables

- `CP`: concentration in the central compartment (`CENT/VC`)

- `RESP`: response (emax model)

### PK parameters

- `KA1`, `KA2`: first order absorption rate constants from first and second extravascular compartment (1/time)

- `CL`: clearance (volume/time)

- `VC`: volume of distribution, central compartment (volume)

- `VP`: volume of distribution, peripheral compartment (volume)

- `VP2`: volume of distribution, peripheral compartment 2 (volume)

- `Q`: intercompartmental clearance (volume/time)

- `Q2`: intercompartmental clearance 2 (volume/time)

- `VMAX`: maximum rate, nonlinear process (mass/time)

- `KM`: Michaelis constant (mass/volume)

- `K10`: elimination rate constant (1/time); `CL/VC`

- `K12`: rate constant for transfer to peripheral compartment from central (1/time); `Q/VC`

- `K21`: rate constant for transfer to central compartment from peripheral (1/time); `Q/VP`

### PD parameters

- `E0`: baseline effect (emax model)

- `EMAX`, `IMAX`: maximum effect (response)

- `EC50`, `IC50`: concentration producing 50 percent of effect (mass/volume)

- `KIN`: zero-order response production rate (irm models) (response/time)

- `KOUT`: first-order response elimination rate (irm models) (1/time)

- `n`: sigmoidicity factor

- `KEO`: rate constant for transfer to effect compartment (1/time)

[Package mrgsolve version 0.11.1 Index]