R: modlib: Pharmacokinetic / pharmacodynamic models

modlib_pkpd {mrgsolve} | R Documentation

## modlib: Pharmacokinetic / pharmacodynamic models

### Description

modlib: Pharmacokinetic / pharmacodynamic models

### Details

See `modlib_details` for more detailed descriptions of parameters and compartments.

All PK/PD models include 2-compartment PK model with absorption from 2 extravascular compartments and linear + nonlinear clearance. The PK models are parameterized with `CL`, `VC`, `Q`, `VMAX`, `KM`, `KA1` and `KA2` and implement compartments `EV1`, `EV2`, `CENT`, `PERIPH` . The indirect response models have compartment `RESP` and the emax model has output variable `RESP`. PD parameters include `KIN`, `KOUT`, `IC50`, `EC50`, `IMAX`, `EMAX`, `E0`, and `n`.

Also, once the model is loaded, use `see` method for `mrgmod` to view the model code.

### Model description

- `irm1` inhibition of response production

- `irm2` inhibition of response loss

- `irm3` stimulation of response production

- `irm4` stimulation of response loss

- `pd_effect` effect compartment model

- `emax` sigmoid emax model

[Package mrgsolve version 0.11.1 Index]