R: Mutagenicity assay

Mutagenicity {mratios} | R Documentation

## Mutagenicity assay

### Description

Mutagenicity assay for 4 doses of a compound (hydroquinone) against a negative (vehicle) control and a positive (active) control (cyclophosphamide). Hydroquinone was applied in doses of 30, 50, 70, 100 mg/kg, positive control was applied with 25mg/kg. Counts of micronuclei in polychromatic erythrocytes after 24h are taken as a measure for the potency to induce chromosome damage. Data of male mice are presented (Hauschke et al., 2005).

### Usage

    data(Mutagenicity)

### Format

A data frame with 31 observations on the following 2 variables.

Treatment

  a factor with levels Cyclo25, Hydro100, Hydro30, Hydro50, Hydro75, Vehicle

MN

  a numeric vector, giving the counts of micronuclei after 24h

### Source

Adler, ID, and Kliesch, U (1990). Comparison of single and multiple treatment regiments in the mouse bone marrow micronucleus assay for hydroquinone and cyclophosphamide. Mutation Research 234, 115-123.

### References

Hauschke, D, Slacik-Erben, R, Hansen, S, Kaufmann,R (2005). Biostatistical Assessment of mutagenicity studies by including the positive control. Biometrical Journal 47, 82-87.

### Examples

    data(Mutagenicity)

    str(Mutagenicity)

    boxplot(MN~Treatment, data=Mutagenicity)

[Package mratios version 1.3.17 Index]