R: Generate a Balanced Code Fingerprint

balance {fingerprint} | R Documentation

## Generate a Balanced Code Fingerprint

### Description

It has been noted that the bit density in a fingerprint can affect its ability to retrieve similar compounds from a database primarily due to complexity effects. One approach to alleviating these effects is to generate fingerprints that have a bit density of 50 balanced code approach described by Nisius and Bajorath to convert an ordinary binary fingerprint (whose bit density is not 50 50 (resulting in a fingerprint twice the size of the original).

### Usage

    balance(fplist)

### Arguments

`fplist` | A single fingerprint or a list of fingerprints

### Value

A single fingerprint objects or list of fingerprint objects that are "balanced", in that they have a bit density of 50 fingerprints.

### Author(s)

Rajarshi Guha rajarshi.guha@gmail.com

### References

Nisius, B.; Bajorath, J.; ChemMedChem, 2010, 5, 859-868.

### See Also

`bit.spectrum`, `bit.importance`

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