R: Creating isobolograms

isobole {drc} | R Documentation

## Creating isobolograms

### Description

'isobole' displays isobole based on EC/ED50 estimates from a log-logistic model. Additionally isoboles determined by the concentration addition model, Hewlett's model and Voelund's model can be added to the plot.

### Usage

    isobole(object1, object2, exchange = 1, cifactor = 2, ename = "e",
    xaxis = "100", xlab, ylab, xlim, ylim, ...)

### Arguments

`object1` | object of class 'drc' where EC/ED50 parameters vary freely.
`object2` | object of class 'drc' where EC/ED50 parameters vary according to Hewlett's model.
`ename` | character string. The name of the EC/ED50 variable.
`xaxis` | character string. Is the mixture "0:100" or "100:0" on the x axis?
`exchange` | numeric. The exchange rate between the two substances.
`cifactor` | numeric. The factor to be used in the confidence intervals. Default is 2, but 1 has been used in publications.
`xlab` | an optional label for the x axis.
`ylab` | an optional label for the y axis.
`xlim` | a numeric vector of length two, containing the lower and upper limit for the x axis.
`ylim` | a numeric vector of length two, containing the lower and upper limit for the y axis.
`...` | Additional graphical parameters.

### Details

The model fits to be supplied as first and optionally second argument are obtained using `mixture` and `drm`.

### Value

No value is returned. Only used for the side effect: the isobologram shown.

### Author(s)

Christian Ritz

### References

Ritz, C. and Streibig, J. C. (2014) From additivity to synergism - A modelling perspective Synergy, 1, 22–29.

### See Also

The examples in `acidiq`, `glymet` and `mecter`.

[Package drc version 3.0-1 Index]