R: Closed Chamber Study of CCl4 Metabolism by Rats.

ccl4data {deSolve} | R Documentation

## Closed Chamber Study of CCl4 Metabolism by Rats.

### Description

The results of a closed chamber experiment to determine metabolic parameters for CCl4 (carbon tetrachloride) in rats.

### Usage

    data(ccl4data)

### Format

This data frame contains the following columns:

time

  the time (in hours after starting the experiment).

initconc

  initial chamber concentration (ppm).

animal

  this is a repeated measures design; this variable indicates which animal the observation pertains to.

ChamberConc

  chamber concentration at `time`, in ppm.

### Source

Evans, et al. 1994 Applications of sensitivity analysis to a physiologically based pharmacokinetic model for carbon tetrachloride in rats. Toxicology and Applied Pharmacology 128: 36 – 44.

### Examples

    plot(ChamberConc ~ time, data = ccl4data, xlab = "Time (hours)",
      xlim = range(c(0, ccl4data$time)),
      ylab = "Chamber Concentration (ppm)", log = "y")
    ccl4data.avg <- aggregate(ccl4data$ChamberConc,
                      by = ccl4data[c("time", "initconc")], mean)
    points(x ~ time, data = ccl4data.avg, pch = 16)

[Package deSolve version 1.28 Index]