R: Genetic Components of Alcoholism

alpha {coin} | R Documentation

## Genetic Components of Alcoholism

### Description

Levels of expressed alpha synuclein mRNA in three groups of allele lengths of NACP-REP1.

### Usage

    alpha

### Format

A data frame with 97 observations on 2 variables.

`alength`

  allele length, a factor with levels `"short"`, `"intermediate"` and `"long"`.

`elevel`

  expression levels of alpha synuclein mRNA.

### Details

Various studies have linked alcohol dependence phenotypes to chromosome 4. One candidate gene is NACP (non-amyloid component of plaques), coding for alpha synuclein. Bönsch et al. (2005) found longer alleles of NACP-REP1 in alcohol-dependent patients compared with healthy controls and reported that the allele lengths show some association with levels of expressed alpha synuclein mRNA.

### Source

Bönsch, D., Lederer, T., Reulbach, U., Hothorn, T., Kornhuber, J. and Bleich, S. (2005). Joint analysis of the NACP-REP1 marker within the alpha synuclein gene concludes association with alcohol dependence. Human Molecular Genetics 14(7), 967–971.

### References

Hothorn, T., Hornik, K., van de Wiel, M. A. and Zeileis, A. (2006). A Lego system for conditional inference. The American Statistician 60(3), 257–263.

### Examples

    ## Boxplots
    boxplot(elevel ~ alength, data = alpha)

    ## Asymptotic Kruskal-Wallis test
    kruskal_test(elevel ~ alength, data = alpha)

[Package coin version 1.1-3 Index]