R: Calculates the difference in the loading score for cell-cycle...

bootstrap_diff {ccRemover} | R Documentation

## Calculates the difference in the loading score for cell-cycle and control genes

### Description

This function is only used internally inside ccRemover. The function calcualtes the average load difference on the cell-cycle and control genes. Bootstrap resampling is then used to provide a score for each component. Please see the original manuscript for the mathematical details.

### Usage

    bootstrap_diff(xy, xn, nboot = 200, bar = TRUE)

### Arguments

`xy` | The data for the genes which are annotated to the cell-cycle, i.e. those genes for which "if_cc" is `TRUE`.
`xn` | The data for the genes which are not annotated to the cell-cycle, control genes, genes for which "if_cc" is `FALSE`
`nboot` | The number of bootstrap repititions to be carried out on each iteration to determine the significance of each component.
`bar` | Whether to display a progress bar or not. The progress bar will not work in R-markdown enviornments so this option may be turned off. The default value is `TRUE`.

### Value

A data frame containing the loadings for each component on the cell-cycle and control genes as well as the difference between the loadings and the bootstrapped statistic for each loading.

[Package ccRemover version 1.0.4 Index]