R: Genetic distances between populations

dist.genpop {adegenet} | R Documentation

## Genetic distances between populations

### Description

This function computes measures of genetic distances between populations using a `genpop` object.
Currently, five distances are available, some of which are euclidian (see details).

A non-euclidian distance can be transformed into an Euclidean one using `cailliez` in order to perform a Principal Coordinate Analysis `dudi.pco` (both functions in `ade4`).

The function `dist.genpop` is based on former `dist.genet` function of `ade4` package.

### Usage

    dist.genpop(x, method = 1, diag = FALSE, upper = FALSE)

### Arguments

`x` | a list of class `genpop`
`method` | an integer between 1 and 5. See details
`diag` | a logical value indicating whether the diagonal of the distance matrix should be printed by `print.dist`
`upper` | a logical value indicating whether the upper triangle of the distance matrix should be printed by `print.dist`

### Details

Let A a table containing allelic frequencies with t populations (rows) and m alleles (columns).
Let ν the number of loci. The locus j gets m(j) alleles. m=∑_{j=1}^{ν} m(j)

For the row i and the modality k of the variable j, notice the value a_{ij}^k (1 ≤q i ≤q t, 1 ≤q j ≤q ν, 1 ≤q k ≤q m(j)) the value of the initial table.

a_{ij}^+=∑_{k=1}^{m(j)}a_{ij}^k and p_{ij}^k=\frac{a_{ij}^k}{a_{ij}^+}

Let P the table of general term p_{ij}^k
p_{ij}^+=∑_{k=1}^{m(j)}p_{ij}^k=1, p_{i+}^+=∑_{j=1}^{ν}p_{ij}^+=ν, p_{++}^+=∑_{j=1}^{ν}p_{i+}^+=tν

The option `method` computes the distance matrices between populations using the frequencies p_{ij}^k.

1. Nei's distance (not Euclidean):
D_1(a,b)=- \ln(\frac{∑_{k=1}^{ν} ∑_{j=1}^{m(k)} p_{aj}^k p_{bj}^k}{√{∑_{k=1}^{ν} ∑_{j=1}^{m(k)} {(p_{aj}^k) }^2}√{∑_{k=1}^{ν} ∑_{j=1}^{m(k)} {(p_{bj}^k)}^2}})

2. Angular distance or Edwards' distance (Euclidean):
D_2(a,b)=√{1-\frac{1}{ν} ∑_{k=1}^{ν} ∑_{j=1}^{m(k)} √{p_{aj}^k p_{bj}^k}}

3. Coancestrality coefficient or Reynolds' distance (Eucledian):
D_3(a,b)=√{\frac{∑_{k=1}^{ν} ∑_{j=1}^{m(k)}{(p_{aj}^k - p_{bj}^k)}^2}{2 ∑_{k=1}^{ν} (1- ∑_{j=1}^{m(k)}p_{aj}^k p_{bj}^k)}}

4. Classical Euclidean distance or Rogers' distance (Eucledian):
D_4(a,b)=\frac{1}{ν} ∑_{k=1}^{ν} √{\frac{1}{2} ∑_{j=1}^{m(k)}{(p_{aj}^k - p_{bj}^k)}^2}

5. Absolute genetics distance or Provesti 's distance (not Euclidean):
D_5(a,b)=\frac{1}{2{ν}} ∑_{k=1}^{ν} ∑_{j=1}^{m(k)} |p_{aj}^k - p_{bj}^k|

### Value

returns a distance matrix of class `dist` between the rows of the data frame

### Author(s)

Thibaut Jombart t.jombart@imperial.ac.uk
Former dist.genet code by Daniel Chessel chessel@biomserv.univ-lyon1.fr
and documentation by Anne B. Dufour dufour@biomserv.univ-lyon1.fr

### References

To complete informations about distances:

Distance 1:
Nei, M. (1972) Genetic distances between populations. American Naturalist, 106, 283–292.
Nei M. (1978) Estimation of average heterozygosity and genetic distance from a small number of individuals. Genetics, 23, 341–369.
Avise, J. C. (1994) Molecular markers, natural history and evolution. Chapman & Hall, London.

Distance 2:
Edwards, A.W.F. (1971) Distance between populations on the basis of gene frequencies. Biometrics, 27, 873–881.
Cavalli-Sforza L.L. and Edwards A.W.F. (1967) Phylogenetic analysis: models and estimation procedures. Evolution, 32, 550–570.
Hartl, D.L. and Clark, A.G. (1989) Principles of population genetics. Sinauer Associates, Sunderland, Massachussetts (p. 303).

Distance 3:
Reynolds, J. B., B. S. Weir, and C. C. Cockerham. (1983) Estimation of the coancestry coefficient: basis for a short-term genetic distance. Genetics, 105, 767–779.

Distance 4:
Rogers, J.S. (1972) Measures of genetic similarity and genetic distances. Studies in Genetics, Univ. Texas Publ., 7213, 145–153.
Avise, J. C. (1994) Molecular markers, natural history and evolution. Chapman & Hall, London.

Distance 5:
Prevosti A. (1974) La distancia genetica entre poblaciones. Miscellanea Alcobe, 68, 109–118.
Prevosti A., Oca\~na J. and Alonso G. (1975) Distances between populations of Drosophila subobscura, based on chromosome arrangements frequencies. Theoretical and Applied Genetics, 45, 231–241.

For more information on dissimilarity indexes:
Gower J. and Legendre P. (1986) Metric and Euclidean properties of dissimilarity coefficients. Journal of Classification, 3, 5–48

Legendre P. and Legendre L. (1998) Numerical Ecology, Elsevier Science B.V. 20, pp274–288.

### See Also

`cailliez`,`dudi.pco`

### Examples

    ## Not run:
    data(microsatt)
    obj <- as.genpop(microsatt$tab)

    listDist <- lapply(1:5, function(i) cailliez(dist.genpop(obj,met=i)))
    for(i in 1:5) {attr(listDist[[i]],"Labels") <- popNames(obj)}
    listPco <- lapply(listDist, dudi.pco,scannf=FALSE)

    par(mfrow=c(2,3))
    for(i in 1:5) {scatter(listPco[[i]],sub=paste("Dist:", i))}

    ## End(Not run)

[Package adegenet version 2.1.4 Index]