{% extends "humanization/designer_layout.html" %} {% set title = result.input.name + " - Designer" %} {% set MIN_SUBJ = result.oasis_params.min_fraction_subjects %} {% set MIN_SAPIENS_SCORE = 0.01 %} {% set MIN_FAMILY_FREQ = 0.005 %} {% set RARE_FAMILY_FREQ = 0.01 %} {% from 'humanization/humanize_alignment_component.html' import format_percent_subjects, format_aa_frequency with context %} {% macro format_aa_frequency_tooltip(v_germline_family, aa, freqs) %} {% if freqs %} Frequency in {{ v_germline_family }}: {{ aa }}={{ format_aa_frequency(freqs.get(aa, 0) if freqs else none) }} {% else %} Frequency for {{ v_germline_family }} not available {% endif %} {% endmacro %} {% block main %}
This corresponds to the {{ '{:.0%}'.format(result.humanized_humanness.get_oasis_percentile(MIN_SUBJ)) }} percentile {{ info_icon('Percentile of OASis identity among therapeutic mAbs at the current prevalence threshold. Zero percentile corresponds to the least human and 100% percentile corresponds to the most human mAb in the clinic, including all clinical stage human, humanized and murine therapeutics.') }}
{{ result.humanized_humanness.vh.v_germline_family }}{{ result.humanized_humanness.vh.v_germline_suffix }} {% if result.humanized_humanness.vh and result.humanized_humanness.vl %}+{% endif %} {{ result.humanized_humanness.vl.v_germline_family }}{{ result.humanized_humanness.vl.v_germline_suffix }}