{% extends "humanization/humanize_layout.html" %} {% set title = "Humanization Result" %} {% set SORTABLE = 'sortable' if not has_next_page and not has_prev_page %} {% set RARE_FAMILY_FREQUENCY = 0.01 %} {% from 'humanization/humanize_alignment_component.html' import oasis_sequence_pair with context %} {% block main %}
{% with result = results[0] %} {% include 'humanization/humanize_params_summary.html' %} {% endwith %}
{% if has_both_chain_types and num_unpaired %}OASis identity {{ info_icon('Fraction of 9-mer peptides considered human based on given prevalence threshold') }} | OASis percentile {{ info_icon('Percentile of OASis identity among therapeutic mAbs at the current prevalence threshold. Zero percentile corresponds to the least human and 100% percentile corresponds to the most human mAb in the clinic, including all clinical stage human, humanized and murine therapeutics.') }} | Germline content {{ info_icon('Sequence identity with nearest heavy and light human germline sequences') }} | Germlines {{ info_icon('Nearest human germline genes based on sequence similarity.') }} | Humanizing mutations {{ info_icon('Number of humanizing mutations made to the parental sequence.') }} | |||||||||||||||||||||
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Name | Before | After | Before | After | Before | After | VH | VL | VH | VL | Actions | ||||||||||||||
{{ result.input.name }} | {% if isinstance(result, Exception) %}Failed: {{ result }} | {% else %}{{ '{:.0%}'.format(result.parental_humanness.get_oasis_identity(min_subj)) }} | {{ '{:.0%}'.format(result.humanized_humanness.get_oasis_identity(min_subj)) }} | {{ '{:.0%}'.format(result.parental_humanness.get_oasis_percentile(min_subj)) }} | {{ '{:.0%}'.format(result.humanized_humanness.get_oasis_percentile(min_subj)) }} | {{ '{:.0%}'.format(result.parental_humanness.get_germline_content()) }} | {{ '{:.0%}'.format(result.humanized_humanness.get_germline_content()) }} | {% if result.humanized_humanness.vh %}{{ result.humanized_humanness.vh.v_germline_names[0] }} | {% else %}- | {% endif %} {% if result.humanized_humanness.vl %}{{ result.humanized_humanness.vl.v_germline_names[0] }} | {% else %}- | {% endif %} {% if result.humanization.vh %}{{ result.humanization.vh.num_mutations() }} | {% else %}- | {% endif %} {% if result.humanization.vl %}{{ result.humanization.vl.num_mutations() }} | {% else %}- | {% endif %} {% endif %}Detail |