{% extends "humanization/humanness_layout.html" %} {% set title = result.input.name + " - Humanness Report" %} {% set MIN_SUBJ = result.oasis_params.min_fraction_subjects %} {% set RARE_FAMILY_FREQUENCY = 0.01 %} {% from 'humanization/humanize_alignment_component.html' import chain_humanness_header, format_sequence_tooltip, format_percent_subjects, format_aa_frequency_tooltip, format_aa_frequency, annot_num with context %} {% block main %}
{{ result.humanness.get_num_human_peptides(MIN_SUBJ) }}/{{ result.humanness.get_num_peptides() }} peptides are considered human
(are found in at least {{ '{:.0%}'.format(MIN_SUBJ) }} of human subjects)
This corresponds to the {{ '{:.0%}'.format(result.humanness.get_oasis_percentile(MIN_SUBJ)) }} percentile {{ info_icon('Percentile of OASis identity among therapeutic mAbs at the current prevalence threshold. Zero percentile corresponds to the least human and 100% percentile corresponds to the most human mAb in the clinic, including all clinical stage human, humanized and murine therapeutics.') }}
Sequence identity with nearest heavy and light human germline sequences.
{{ result.humanness.vh.v_germline_family }}{{ result.humanness.vh.v_germline_suffix }} {% if result.humanness.vh and result.humanness.vl %}+{% endif %} {{ result.humanness.vl.v_germline_family }}{{ result.humanness.vl.v_germline_suffix }}
Position | Amino acid | OASis 9-mer peptide search | ||||||
---|---|---|---|---|---|---|---|---|
Region | {{ list(chain_humanness.peptides)[0].scheme.title() }} | AA | Chain Freq {{ info_icon('Residue frequency in {} chain at given {} position'.format(chain_humanness.chain.chain_type, chain_humanness.chain.scheme.title())) }} |
Family Freq {{ info_icon('Residue frequency in {} germline family at given {} position'.format(chain_humanness.v_germline_family, chain_humanness.chain.scheme.title())) }} |
Peptide {{ info_icon('9-mer peptide starting at given position.') }} | OAS Subjects {{ info_icon('Percentage of OAS human subjects containing this peptide in their repertoire.') }} |
OAS Sequences {{ info_icon('Number of total antibody sequences containing this peptide across across all human subjects in OAS.') }} |